Ted Zwang
Ted Zwang earned the Toffler Scholar Award in 2023 at Harvard
Biography
Ted Zwang was born in Danbury, Connecticut, where he and his family lived for three years before they relocated to Houston, Texas. When Dr. Zwang was in middle school, the family moved once more — this time to a small rural town in western New Jersey. Dr. Zwang’s father worked in IT infrastructure and his mother was an artist.
While some people think of video games and sports as opposite ends of a spectrum, Dr. Zwang enjoyed both when he was growing up. He loved playing video games like Starcraft, Rollercoaster Tycoon, and Pokemon with his friends — and sometimes his mom. On the athletic side, Dr. Zwang played soccer for a travel team. He also loved fencing and excelled at the sport, competing at tournaments internationally and across the country. He considered pursuing fencing in college, but ultimately decided his time would be better spent discovering and exploring what his other passions may be. He found the perfect place to do that: Pomona College in California.
Growing up, Dr. Zwang always enjoyed math and science, and excelled in those subjects. But when he started his undergraduate studies, he had no intention of becoming a research scientist. He wasn’t sure what he wanted to be. Maybe he wanted to be a high school teacher? Or a park ranger? One thing he did know was that he enjoyed spending summer on campus in California, which his organic chemistry TA overheard and led to him being introduced to Professor Malkiat Johal. Professor Johal gave Dr. Zwang his first real research opportunity, which involved using surface chemistry to study solid supported lipid bilayer systems. During that summer, Dr. Zwang fell in love with the idea of pursuing a career in science. He learned how much fun it was to perform research and the faculty at Pomona College gave him freedom to explore many exciting directions. Over the next couple of years, he found excuses to work with a variety of faculty on different research projects. These projects included Professors Matthew Sazinsky and Cynthia Selassie, among others, all of whom helped foster a love for collaborative and multidisciplinary science. These experiences bolstered Dr. Zwang’s newfound passion for scientific research.
After completing his Bachelor of Arts Degree at Pomona college, Dr. Zwang went on to get his PhD in Chemistry from Caltech. While there, he found a place in Professor Jacqueline Barton's lab researching how DNA uses electrochemistry to aid in the ability to find damage and repair it. He credits Dr. Barton for making him the
rigorous and resourceful scientist that he is today. He has particularly fond memories of the way that Professor Barton ran her lab, and that she would let people pursue their own novel research ideas if they were passionate about the idea and if they could convince her it was a good idea. This was no easy feat, but it helped teach Dr. Zwang how to plan and present complex research ideas. Dr. Zwang managed to convince Dr. Barton to let him research spin effects in charge transport, which led to his published work describing how the three-dimensional shape of DNA can influence the ability for electron spin states to move through DNA and how biology might take advantage of such phenomena.
After earning his PhD, he accepted a position as a postdoctoral research fellow at Harvard in the lab of Professor Charles Lieber that was developing electronics that could be implanted in the brain and record brain activity from neurons over long periods of time. Dr. Zwang enjoyed his time developing this vital technology but found inspiration in trying to use the technology to understand how brain activity changes as people age. That’s when he reached out to Professor Chris Harvey at Harvard Medical School, who taught Dr. Zwang how to build and utilize virtual reality (VR) systems for neuroscience, and Professor Bradley Hyman at Massachusetts General Hospital, who taught Dr. Zwang about Alzheimer’s disease — both key components of his research today.
Now Dr. Ted Zwang is an Assistant Professor of Neurology at Massachusetts General Hospital and Harvard Medical School. He is deploying flexible neuron-like electronics in combination with VR experiments to understand how cognitive dysfunction arises from aging and Alzheimer’s disease.
“I love science because there's something special about doing things that no one really knows how to do. It’s fun seeing what can be done and finding creativity in solving problems within time, budget, and experimental constraints.”
- Dr. Ted Zwang
BIOGRAPHY
Ted Zwang was born in Danbury, Connecticut, where he and his family lived for three years before they relocated to Houston, Texas. When Dr. Zwang was in middle school, the family moved once more — this time to a small rural town in western New Jersey. Dr. Zwang’s father worked in IT infrastructure and his mother was an artist.
While some people think of video games and sports as opposite ends of a spectrum, Dr. Zwang enjoyed both when he was growing up. He loved playing video games like Starcraft, Rollercoaster Tycoon, and Pokemon with his friends — and sometimes his mom. On the athletic side, Dr. Zwang played soccer for a travel team. He also loved fencing and excelled at the sport, competing at tournaments internationally and across the country. He considered pursuing fencing in college, but ultimately decided his time would be better spent discovering and exploring what his other passions may be. He found the perfect place to do that: Pomona College in California.
Growing up, Dr. Zwang always enjoyed math and science, and excelled in those subjects. But when he started his undergraduate studies, he had no intention of becoming a research scientist. He wasn’t sure what he wanted to be. Maybe he wanted to be a high school teacher? Or a park ranger? One thing he did know was that he enjoyed spending summer on campus in California, which his organic chemistry TA overheard and led to him being introduced to Professor Malkiat Johal. Professor Johal gave Dr. Zwang his first real research opportunity, which involved using surface chemistry to study solid supported lipid bilayer systems. During that summer, Dr. Zwang fell in love with the idea of pursuing a career in science. He learned how much fun it was to perform research and the faculty at Pomona College gave him freedom to explore many exciting directions. Over the next couple of years, he found excuses to work with a variety of faculty on different research projects. These projects included Professors Matthew Sazinsky and Cynthia Selassie, among others, all of whom helped foster a love for collaborative and multidisciplinary science. These experiences bolstered Dr. Zwang’s newfound passion for scientific research.
After completing his Bachelor of Arts Degree at Pomona college, Dr. Zwang went on to get his PhD in Chemistry from Caltech. While there, he found a place in Professor Jacqueline Barton's lab researching how DNA uses electrochemistry to aid in the ability to find damage and repair it. He credits Dr. Barton for making him the rigorous and resourceful scientist that he is today. He has particularly fond memories of the way that Professor Barton ran her lab, and that she would let people pursue their own novel research ideas if they were passionate about the idea and if they could convince her it was a good idea. This was no easy feat, but it helped teach Dr. Zwang how to plan and present complex research ideas. Dr. Zwang managed to convince Dr. Barton to let him research spin effects in charge transport, which led to his published work describing how the three-dimensional shape of DNA can influence the ability for electron spin states to move through DNA and how biology might take advantage of such phenomena.
After earning his PhD, he accepted a position as a postdoctoral research fellow at Harvard in the lab of Professor Charles Lieber that was developing electronics that could be implanted in the brain and record brain activity from neurons over long periods of time. Dr. Zwang enjoyed his time developing this vital technology but found inspiration in trying to use the technology to understand how brain activity changes as people age. That’s when he reached out to Professor Chris Harvey at Harvard Medical School, who taught Dr. Zwang how to build and utilize virtual reality (VR) systems for neuroscience, and Professor Bradley Hyman at Massachusetts General Hospital, who taught Dr. Zwang about Alzheimer’s disease — both key components of his research today.
Now Dr. Ted Zwang is an Assistant Professor of Neurology at Massachusetts General Hospital and Harvard Medical School. He is deploying flexible neuron-like electronics in combination with VR experiments to understand how cognitive dysfunction arises from aging and Alzheimer’s disease.
“I love science because there's something special about doing things that no one really knows how to do. It’s fun seeing what can be done and finding creativity in solving problems within time, budget, and experimental constraints.”
- Dr. Ted Zwang
Research Focus
Challenges
As we age, our brains change in specific ways that lead to cognitive decline and increase the risk of Alzheimer’s disease (AD), a neurodegenerative disease that affects millions of Americans and is the leading cause of dementia among adults. Yet it is difficult to determine precisely when structural changes in the brain lead to behavioral changes, like tremors or memory loss. Additionally, it has been difficult to determine the signals that lead to a quantitative diagnosis for neurodegeneration and AD.
Focus and Priorities
Dr. Zwang is working to create an understanding of aging neural circuitry and how molecular and cellular changes lead to cognitive decline. If scientists and doctors can understand which small changes in the brain indicate neurodegeneration is happening and predict the trajectory of these changes, it will be possible to make earlier diagnoses and more precisely monitor the effectiveness of treatments. Ideally this will allow treatments to be given early enough that they delay or prevent trademark behaviors of Alzheimer’s disease from manifesting. As part of his research, Dr. Zwang
uses brain probes that mimic aspects of neurons to record brain activity and VR systems to simulate behaviors that become dysfunctional with neurodegeneration. By employing this technology, he and his team can get a sense of what's happening in the brain over very long periods of time before, during and after the onset of pathology. By focusing on the ways that brain activity changes as individual neurons and their circuits age with pathology, they can begin to understand how small and early changes in the brain cascade into cognitive deficits and dementia.
Benefits
Dr. Zwang hopes that through this research, he and his team will be able to see the influence that tau pathology has on the brain before it causes parts of the brain to die. If able to understand early changes in the brain, doctors can diagnose AD earlier in patients, which could lead to more effective, early-stage treatments before symptoms even appear.
In addition, Dr. Zwang sees applications of this technology beyond tau pathology. His hope is that he will eventually be able to differentiate between forms of pathology by monitoring the brain during different types of tasks. He also believes they might be able to find different electronic signatures that help doctors effectively split people into different clinical cohorts, allowing for more effective treatments over time for a wide variety of conditions — not just AD.
Karen Toffler Charitable Trust Investment
Funding from the Karen Toffler Charitable Trust will enable Dr. Zwang to hire and train programmers to support his research and develop virtual reality methods for monitoring the trajectory of dementia. To be effective, the technology needs to register the right signals that match with specific behaviors. By employing people with programming skills, Dr. Zwang can leverage their background and expertise while giving them experience in neuroscience and research, two areas that are rich with opportunity for programmers who want to make an impact in the world of medicine.
Karen Toffler Charitable Trust Investment
Funding from the Karen Toffler Charitable Trust will enable Dr. Zwang to hire and train programmers to support his research and develop virtual reality methods for monitoring the trajectory of dementia. To be effective, the technology needs to register the right signals that match with specific behaviors. By employing people with programming skills, Dr. Zwang can leverage their background and expertise while giving them experience in neuroscience and research, two areas that are rich with opportunity for programmers who want to make an impact in the world of medicine.
“I think a lot of people don’t realize how many pathways there are to a career that helps us learn more about diseases that impact people today. Many people I know struggle with the idea of trying to find more meaningful things to do in their lives, and there is a lot of room for people to do really important work in this area.”
- Dr. Ted Zwang